Inhibition of estrone sulfatase (ES) by alkyl and cycloalkyl ester derivatives of 4-[(aminosulfonyl)oxy] benzoic acidPATEL, Chirag K; OWEN, Caroline P; AHMED, Sabbir et al.Bioorganic & medicinal chemistry letters (Print). 2004, Vol 14, Num 3, pp 605-609, issn 0960-894X, 5 p.Article

Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES)AHMED, Sabbir; JAMES, Karen; OWEN, Caroline P et al.Journal of steroid biochemistry and molecular biology. 2002, Vol 82, Num 4-5, pp 425-435, issn 0960-0760, 11 p.Article

Inhibition of estrone sulfatase (ES) by derivatives of 4-[(aminosulfonyl)oxy] benzoic acidAHMED, Sabbir; JAMES, Karen; OWEN, Caroline P et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 17, pp 2391-2394, issn 0960-894XArticle

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17α-hydroxylase/17,20-lyase (P450_17α)PATEL, Chirag H; DHANANI, Sachin; OWEN, Caroline P et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 18, pp 4752-4756, issn 0960-894X, 5 p.Article

Design, synthesis and biochemical evaluation of AC ring mimics as novel inhibitors of the enzyme estrone sulfatase (ES)AHMED, Sabbir; JAMES, Karen; OWEN, Caroline P et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 10, pp 1343-1346, issn 0960-894XArticle

Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17α-hydroxylase/17,20-lyase (P-450_17α)AHMED, Sabbir; SHAHID, Imran; DHANANI, Sachin et al.Bioorganic & medicinal chemistry letters (Print). 2009, Vol 19, Num 16, pp 4698-4701, issn 0960-894X, 4 p.Article

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a series of 4-hydroxyphenyl ketones as potential inhibitors of 17β-hydroxysteroid dehydrogenase type 3 (17β-HSD3)LOTA, Rupinder K; DHANANI, Sachin; OWEN, Caroline P et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 17, pp 4519-4522, issn 0960-894X, 4 p.Article

Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17α-hydroxylase/17,20-lyase (P450_17α) derived from rat testicular microsomesOWEN, Caroline P; SHAHID, Imran; LEE, Wai-Yee et al.Bioorganic & medicinal chemistry letters (Print). 2010, Vol 20, Num 17, pp 5345-5348, issn 0960-894X, 4 p.Article

Synthesis and biochemical evaluation of novel and potent inhibitors of the enzyme oestrone sulphatase (ES)AHMED, Sabbir; JAMES, Karen; OWEN, Caroline P et al.Journal of steroid biochemistry and molecular biology. 2002, Vol 80, Num 4-5, pp 419-427, issn 0960-0760Article

Review of estrone sulfatase and its inhibitors: An important new target against hormone dependent breast cancerAHMED, Sabbir; OWEN, Caroline P; JAMES, Karen et al.Current medicinal chemistry. 2002, Vol 9, Num 2, pp 263-273, issn 0929-8673Article

The mechanism of the irreversible inhibition of estrone sulfatase (ES) through the consideration of a range of methane- and amino-sulfonate-based compoundsAHMED, Sabbir; JAMES, Karen; OWEN, Caroline P et al.Bioorganic & medicinal chemistry letters (Print). 2002, Vol 12, Num 9, pp 1279-1282, issn 0960-894XArticle

Hydrophobicity, a physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES)AHMED, Sabbir; JAMES, Karen; OWEN, Caroline P et al.Bioorganic & medicinal chemistry letters (Print). 2001, Vol 11, Num 18, pp 2525-2528, issn 0960-894XArticle

Novel inhibitors of the enzyme estrone sulfatase (ES)AHMED, Sabbir; JAMES, Karen; OWEN, Caroline P et al.Bioorganic & medicinal chemistry letters (Print). 2001, Vol 11, Num 6, pp 841-844, issn 0960-894XArticle

A novel steroidal saponin glycoside from Fagonia indica induces cell-selective apoptosis or necrosis in cancer cellsWAHEED, Abdul; BARKER, James; BARTON, Stephen J et al.European journal of pharmaceutical sciences. 2012, Vol 47, Num 2, pp 464-473, issn 0928-0987, 10 p.Article

Acid dissociation constant, a potential physicochemical factor in the inhibition of the enzyme estrone sulfatase (ES)AHMED, Sabbir; OWEN, Caroline P; JAMES, Karen et al.Bioorganic & medicinal chemistry letters (Print). 2001, Vol 11, Num 7, pp 899-902, issn 0960-894XArticle

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17a-hydroxylase/17,20-lyase (P450_17α)OWEN, Caroline P; SHAHID, Imran; OLUSANJO, Moniola S et al.Journal of steroid biochemistry and molecular biology. 2008, Vol 111, Num 1-2, pp 117-127, issn 0960-0760, 11 p.Article

Structure-activity relationship determination within a group of substituted phenyl sulfamate based compounds against the enzyme oestrone sulfatasePATEL, Chirag K; GALISSON, Angelique; JAMES, Karen et al.Journal of pharmacy and pharmacology. 2003, Vol 55, Num 2, pp 211-218, issn 0022-3573, 8 p.Article

Determination and use of a transition state for the enzyme estrone sulfatase (ES) from a proposed reaction mechanismAHMED, Sabbir; JAMES, Karen; OWEN, Caroline P et al.Bioorganic & medicinal chemistry letters (Print). 2001, Vol 11, Num 23, pp 3001-3005, issn 0960-894XArticle

Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-hydroxyphenyl ketones as potent and specific inhibitors of the type 3 of 17β-hydroxysteroid dehydrogenase (17β-HSD3)LOTA, Rupinder K; OLUSANJO, Moniola S; DHANANI, Sachin et al.Journal of steroid biochemistry and molecular biology. 2008, Vol 111, Num 1-2, pp 128-137, issn 0960-0760, 10 p.Article

Synthesis, biochemical evaluation of a range of potent 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17a-Hydroxylase/17,20-Lyase(P45017α)SHAHID, Imran; PATEL, Chirag H; DHANANI, Sachin et al.Journal of steroid biochemistry and molecular biology. 2008, Vol 110, Num 1-2, pp 18-29, issn 0960-0760, 12 p.Article

Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17α-hydroxylase/17,20-lyase (P450_17α)OWEN, Caroline P; DHANANI, Sachin; PATEL, Chirag H et al.Bioorganic & medicinal chemistry letters (Print). 2006, Vol 16, Num 15, pp 4011-4015, issn 0960-894X, 5 p.Article

Evidence for the mechanism of the irreversible inhibition of oestrone sulphatase (ES) by aminosulphonate based compoundsAHMED, Sabbir; OWEN, Caroline P; JAMES, Karen et al.Journal of steroid biochemistry and molecular biology. 2002, Vol 80, Num 4-5, pp 429-440, issn 0960-0760Article